The resolution directly contradicts statements made by US President Donald Trump, who has insisted repeatedly there is no definitive evidence connecting MBS with the grisly crime.
But will the senators force Trump to drop his defence of the Saudi royal?
The resolution also criticises Saudi Arabia for the war in Yemen, the blockade of Qatar, and a crackdown on dissent in the kingdom.
It is a testing time for the US president.
John Jones – former senior congressional adviser
Sigurd Neubauer – Middle East analyst with expertise in Gulf affairs
Chris Garcia – former deputy director of the US Department of Commerce
Source: Al Jazeera